Integrin-Induced PIP5K1C Kinase Polarization Regulates Neutrophil Polarization, Directionality, and In Vivo Infiltration

AMP-activated protein kinase regulates neuronal polarization

Question: Does the adenosine 5=monophosphate (AMP)-activated protein kinase (AMPK) signaling cascade have a role in neuronal polarization? Background: The differentiation of a single neurite into an axon, which involves increased protein and membrane synthesis as well as the intracellular trafficking of these products, is a metabolically costly process. The AMPK signaling cascade has a major ro...

Directionality in the WMAP Polarization Data

Polarization is the next frontier of CMB analysis, but its signal is dominated over much of the sky by foregrounds which must be carefully removed. To determine the efficacy of this cleaning it is necessary to have sensitive tests for residual foreground contamination in polarization sky maps. The dominant Galactic foregrounds introduce a large-scale anisotropy on to the sky, so it makes sense ...

P130: The Role of Rho-Kinase (ROCK) in Microglia/Macrophage Polarization in Neuroinflammatory Diseases

Macrophage/microglia with heterogonous phenotype and function under physiological and pathological conditions are the main cell lineage involved in inducing immune responses in neuroinflammatory diseases which exhibit combined inflammatory and anti-inflammatory functions. An increase in the expression of iNOS triggers M1 phenotype that secrete high concentrations of inflammatory cytokines, whil...

Sedoheptulose Kinase Regulates Glucose Metabolism And Immune Cell Polarization

The Lipid Kinase PIP5K1C Regulates Pain Signaling and Sensitization

Numerous pain-producing (pronociceptive) receptors signal via phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis. However, it is currently unknown which lipid kinases generate PIP2 in nociceptive dorsal root ganglia (DRG) neurons and if these kinases regulate pronociceptive receptor signaling. Here, we found that phosphatidylinositol 4-phosphate 5 kinase type 1C (PIP5K1C) is expressed at h...